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What is Remotiv?

Remotiv (Ze 117) is a tablet containing 250 mg of Hypericum perforatum (St John’s Wort) extract, standardised to 500 mcg hypericin.

It is manufactured in Switzerland by Zeller, a herbal medicine company with 135 years of involvement in the research and production of natural medicines. More than 500 million Remotiv tablets have been sold worldwide, equivalent to 6 million treated patients.

What is Remotiv used for?

Remotiv is used in the treatment of:
◾Mild to moderate depression
◾Anxiety, nervous tension and irritability

Safety and Efficacy

The safety and efficacy of Remotiv have been confirmed by a number of controlled clinical trials, compared with either placebo, or well established synthetic antidepressant medicines:
◾Equivalent in efficacy to the SSRI fluoxetine (Prozac), but much better tolerated by the patients;
◾Equivalent in efficacy to the tricyclic antidepressant imipramine, but much better tolerated by the patients.

Results of the clinical studies have been published in reputable medical journals.

Remotiv has no negative effects when taken concurrently with the contraceptive pill.

Sexual dysfunction, frequently experienced by patients taking synthetic antidepressants, does nor occur with Remotiv therapy.

Dosage and Directions for Use

The adult dose of Remotiv is 1 tablet twice daily, to be taken morning and evening. The normal duration of treatment is four to six weeks.

Product precautions

◾St John’s Wort preparations may cause photosensitization (increased sensitivity to the sun and sunburn). At the recommended dosage, however, there have been no reports of photosensitivity with Remotiv.
◾St John’s Wort may lower plasma concentrations of indinavir, cyclosporin, warfarin, digoxin, theophylline and anticonvulsants. Due to the very low content of hyperforin (the constituent of St John’s Wort responsible for drug interactions) in Remotiv these interactions have not been reported in clinical use.
◾Side-effects are generally not encountered, but rare instances of gastro-intestinal discomfort and fatigue have been reported.

Unless advised by a health care professional, Remotiv should not be taken during pregnancy or by breastfeeding mothers, due to lack of clinical evidence in these patient groups.


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