DL-Phenylalanine 250mg



DL-Phenylalanine is a racemic mixture of phenylalanine, an aromatic amino acid with antidepressant, analgesic and appetite suppressant properties. The antidepressant effect of DL-phenylalanine may be accounted for by its precursor role in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects. This agent also plays a role in alleviating mood swings of premenstrual syndrome (PMS), increasing energy and mental alertness,  and heightening the ability to focus in individuals with attention deficit hyperactivity disorder (ADHD).

  • By increasing the levels of internal opioids, D-phenylalanine may improve mood and help people undergoing opiate withdrawal. The clinical data is limited and inconclusive.
  • Some people use DLPA supplements to burn fat and lose weight despite the lack of clinical data to support its efficacy. According to a handful of small trials, L-phenylalanine may reduce food intake and support fat burning.
  • DL-phenylalanine (75-200 mg/day for 20 days) resolved the symptoms of depression in 12 out of 20 patients. It offered mild to moderate benefits in four more patients, while it failed to affect the remaining four.
  • Some doctors have reported positive results in pain management with large doses (1,500-3,000 mg daily) of DLPA. According to them, antidepressant and painkiller effects of DLPA are tightly linked.
  • DLPA improved symptoms such as anger, restlessness, and poor concentration in 19 adults with ADHD. However, 3 months after the study finished, the beneficial effects disappeared.
  • Depression: 50-200 mg for 2-4 weeks [15, 16, 17]
  • Attention Deficit Disorder: increasing from 150 to 1,200 mg daily for two weeks [32]
  • Chronic pain: 1,500-3,000 mg daily (from clinical experience)


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